PES1

Across TCGA patient cohorts, PES1 mutation is significantly associated with the RNA expression of many other genes, with 742 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PES1-associated genes across cancer lineages are RNU7-52P, GNPNAT1, and SEC23A. Each is linked with PES1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PES1-to-partner and partner-to-PES1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-52P grouped by PES1-low versus PES1-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PES1→partner) and Y-score (partner→PES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	RNU7-52P →	+0.503	+7.939	<.001	.008	3	2
UCEC	GNPNAT1 →	+0.514	+1.936	.008	.003	3	2
UCEC	SEC23A →	+0.614	+3.815	<.001	<.001	3	2
UCEC	BAG2 →	+0.645	+3.087	.003	<.001	3	2
UCEC	GBE1 →	+0.689	+2.818	.001	.001	3	2
UCEC	EDEM1 →	+0.560	+2.914	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 742 associations by consensus.

RNU7-52P by PES1 expression — PRAD

Explore this box plot interactively →