PES1

Across TCGA cell cohorts, PES1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PES1-associated genes across cancer lineages are CLEC4C, SPEM3, and AVP. Each is linked with PES1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PES1-to-partner and partner-to-PES1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC4C grouped by PES1-low versus PES1-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PES1→partner) and Y-score (partner→PES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CLEC4C →	+0.045	+4.459	<.001	.001	3	1
LIVER	SPEM3 →	+0.015	+4.459	<.001	.001	3	1
LARGE_INTESTINE	AVP →	+0.056	+3.632	<.001	.003	3	1
LARGE_INTESTINE	C10orf53 →	+0.012	+3.632	<.001	.003	3	1
LARGE_INTESTINE	OR10Q1 →	+0.106	+4.242	<.001	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.269	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CLEC4C by PES1 expression — LIVER

Explore this box plot interactively →