PERP

Across TCGA patient cohorts, PERP mutation is significantly associated with the RNA expression of many other genes, with 332 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PERP-associated genes across cancer lineages are RNU6-434P, KRTAP4-16, and RNU7-128P. Each is linked with PERP in more than 1 cancer types. Because this analysis shows association rather than direction, both PERP-to-partner and partner-to-PERP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-434P grouped by PERP-low versus PERP-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PERP→partner) and Y-score (partner→PERP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RNU6-434P →	+0.392	+5.584	<.001	.003	3	2
GBM	KRTAP4-16 →	+0.451	+5.352	<.001	.005	3	2
UCEC	RNU7-128P →	+0.833	+3.257	<.001	<.001	3	2
GBM	NF1P2 →	+0.028	+5.584	<.001	.003	3	1
GBM	RN7SL383P →	+0.219	+5.352	<.001	.005	3	1
GBM	MIR4694 →	+0.479	+5.352	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 332 associations by consensus.

RNU6-434P by PERP expression — GBM

Explore this box plot interactively →