PER3

Across TCGA pan-cancer cohorts, PER3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PER3 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PER3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PER3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where PER3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.892	0.324	.003	12	view →
PDAC	DFS	Quartile	All	0.147	0.455	.008	12	view →
LSCC	DFS	Median	II,III,IV	0.896	0.985	.048	2	view →
LUAD	OS	Tertile	II,III,IV	0.405	1.000	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PER3–CCRCC (DFS)

Open the CCRCC breakdown →