PER3

Across TCGA pan-cancer cohorts, PER3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PER3’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PER3 RNA is repressed in tumor relative to normal tissue. In most cancer types PER3 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and UCEC are the cancer types where PER3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PER3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	−1.315	<.001	12	view →
COAD	Male	All	−1.266	<.001	11	view →
UCEC	All	III,IV	−2.056	<.001	6	view →
BRCA	All	III,IV	−0.786	<.001	6	view →
READ	Female	All	−2.475	<.001	5	view →
HNSC	Male	All	−0.731	.005	5	view →
STAD	Female	All	−1.454	.004	4	view →
CHOL	All	All	−1.115	.001	4	view →
KICH	All	All	−0.681	.010	3	view →
LUAD	All	All	−0.476	.006	3	view →
LUSC	All	All	−0.573	.005	2	view →
KIRP	All	All	−0.562	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PER3–BLCA

Open the BLCA breakdown →