PER3

Across TCGA patient cohorts, PER3 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PER3-associated genes across cancer lineages are p27_pT157, c-Kit, and eEF2. Each is linked with PER3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PER3-to-partner and partner-to-PER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by PER3-low versus PER3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PER3→partner) and Y-score (partner→PER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p27_pT157 →	+0.186	+2.824	<.001	.034	3	3
SKCM	c-Kit →	-0.607	-2.222	.027	.010	3	3
UCEC	eEF2 →	+0.305	+2.807	.005	.002	3	2
UCEC	ERK2 →	+0.185	+1.643	.001	.003	3	2
UCEC	GAPDH →	+0.396	+1.807	.017	.024	3	2
UCEC	GSK-3_pS9 →	-0.252	-1.247	.045	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

p27_pT157 by PER3 expression — SKCM

Explore this box plot interactively →