PELO

Across TCGA patient cohorts, PELO mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PELO-associated genes across cancer lineages are Cyclin-B1, FoxM1, and Caspase-8. Each is linked with PELO in more than 1 cancer types. Because this analysis shows association rather than direction, both PELO-to-partner and partner-to-PELO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PELO-low versus PELO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PELO→partner) and Y-score (partner→PELO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.759	+3.321	.009	.010	3	2
UCEC	FoxM1 →	+0.345	+3.321	.010	.010	3	1
UCEC	Caspase-8 →	-0.296	-3.321	.024	.010	3	1
UCEC	VHL →	-1.456	-3.000	<.001	.036	2	1
UCEC	Caspase-7-cleavedD198 →	+0.761	+2.827	.014	.035	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Cyclin-B1 by PELO expression — UCEC

Explore this box plot interactively →