PEF1-AS1

Across TCGA pan-cancer cohorts, PEF1-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PEF1-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PEF1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PEF1-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

KIRC, UCS, and HNSC are the cancer types where PEF1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.536	0.697	<.001	113	view →
UCS	DFS	Quartile	III,IV	0.667	0.199	<.001	62	view →
HNSC	DFS	Tertile	III,IV	0.473	0.157	<.001	60	view →
SKCM	DFS	Quartile	All	0.684	0.534	.002	53	view →
THCA	OS	Tertile	All	0.829	1.000	.008	46	view →
LGG	DFS	Median	All	0.663	0.800	<.001	45	view →
ACC	OS	Quartile	All	0.739	0.953	.009	29	view →
LIHC	DFS	Median	All	0.164	0.379	<.001	26	view →
CESC	OS	Median	IV	0.587	0.106	.008	24	view →
BRCA	OS	Tertile	All	0.635	0.522	.003	18	view →
PRAD	DFS	Tertile	All	0.819	0.913	.008	18	view →
KIRP	DFS	Quartile	All	0.433	0.858	.002	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PEF1-AS1–KIRC (DFS)

Open the KIRC breakdown →