PEF1-AS1

Across TCGA pan-cancer cohorts, PEF1-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PEF1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PEF1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PEF1-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and KICH are the cancer types where PEF1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PEF1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.361	<.001	12	view →
THCA	Male	All	−0.451	<.001	9	view →
KICH	Female	All	−0.484	<.001	6	view →
STAD	All	All	+0.318	<.001	6	view →
COAD	All	All	+0.235	<.001	6	view →
KIRC	All	II,III,IV	−0.188	<.001	6	view →
CHOL	All	All	+0.580	<.001	5	view →
LIHC	All	All	+0.033	.004	5	view →
BRCA	All	III,IV	−0.293	.009	4	view →
LUAD	Male	III,IV	−0.244	.030	2	view →
KIRP	Male	All	−0.177	.015	2	view →
LUSC	All	All	+0.147	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PEF1-AS1–HNSC

Open the HNSC breakdown →