PEDS1-UBE2V1

Across TCGA patient cohorts, PEDS1-UBE2V1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEDS1-UBE2V1-associated genes across cancer lineages are FOXO3a_pS318_S321, GSK-3_pS9, and GSK-3a-b_pS21_S9. Each is linked with PEDS1-UBE2V1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEDS1-UBE2V1-to-partner and partner-to-PEDS1-UBE2V1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by PEDS1-UBE2V1-low versus PEDS1-UBE2V1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEDS1-UBE2V1→partner) and Y-score (partner→PEDS1-UBE2V1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.128	-1.690	.015	.042	3	1
UCEC	GSK-3_pS9 →	-0.471	-2.321	.006	.033	3	1
UCEC	GSK-3a-b_pS21_S9 →	-0.430	-3.169	.017	.018	3	1
UCEC	ACC1 →	+0.398	+3.183	.009	.009	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.553	+1.700	.010	.044	3	1
UCEC	MEK1 →	+0.376	+2.584	.015	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

FOXO3a_pS318_S321 by PEDS1-UBE2V1 expression — UCEC

Explore this box plot interactively →