PEDS1-UBE2V1

Across TCGA pan-cancer cohorts, PEDS1-UBE2V1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated PEDS1-UBE2V1 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PEDS1-UBE2V1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PEDS1-UBE2V1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and THCA show a favorable association.

SKCM, OV, and THCA are the cancer types where PEDS1-UBE2V1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	II,III,IV	0.704	0.469	<.001	54	view →
OV	OS	Tertile	All	0.270	0.355	.002	42	view →
THCA	DFS	Median	III,IV	0.955	0.852	.013	40	view →
LIHC	DFS	Tertile	All	0.407	0.607	<.001	25	view →
ACC	DFS	Median	II,III,IV	0.380	0.700	.009	20	view →
SCLC	DFS	Tertile	III,IV	0.649	0.312	.017	15	view →
ESCA	OS	Tertile	III,IV	0.394	0.665	.022	12	view →
BLCA	OS	Tertile	IV	0.235	0.603	.015	9	view →
GBM	OS	Median	All	0.434	0.257	.028	9	view →
SARC	OS	Tertile	All	0.414	0.751	.001	9	view →
PCPG	OS	Tertile	All	0.925	1.000	.017	9	view →
THYM	DFS	Quartile	All	1.000	0.718	.019	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

PEDS1-UBE2V1–SKCM (DFS)

Open the SKCM breakdown →