PECR

Across TCGA patient cohorts, PECR mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PECR-associated genes across cancer lineages are Notch1, EGFR_pY1068, and eIF4E. Each is linked with PECR in more than 1 cancer types. Because this analysis shows association rather than direction, both PECR-to-partner and partner-to-PECR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PECR-low versus PECR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PECR→partner) and Y-score (partner→PECR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.195	+2.115	.001	.019	3	2
UCEC	EGFR_pY1068 →	-0.290	-2.115	.008	.019	3	1
UCEC	eIF4E →	+0.198	+3.335	.031	.005	3	1
UCEC	eIF4G →	+0.365	+3.169	.007	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.141	-2.105	.009	.017	3	1
UCEC	INPP4B →	-0.305	-2.459	.030	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Notch1 by PECR expression — UCEC

Explore this box plot interactively →