PECR

Across TCGA cell cohorts, PECR mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PECR-associated genes across cancer lineages are UTF1, LYPD4, and WSCD2. Each is linked with PECR in more than 1 cancer types. Because this analysis shows association rather than direction, both PECR-to-partner and partner-to-PECR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UTF1 grouped by PECR-low versus PECR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PECR→partner) and Y-score (partner→PECR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UTF1 →	+0.012	+3.217	.001	.006	3	1
LARGE_INTESTINE	LYPD4 →	+0.042	+3.242	.005	.003	3	1
LARGE_INTESTINE	WSCD2 →	+0.124	+3.660	<.001	.005	3	1
LARGE_INTESTINE	SH3GL2 →	+1.395	+3.252	<.001	.009	2	1
LARGE_INTESTINE	HTR3A →	+0.600	+3.392	.002	.007	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

UTF1 by PECR expression — LARGE_INTESTINE

Explore this box plot interactively →