PEBP4

Across TCGA cell cohorts, PEBP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,301 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PEBP4-associated GO terms across cancer lineages are Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Heparan sulfate proteoglycan catabolic process, and Positive regulation of cellular respiration. Each is linked with PEBP4 in more than 8 cancer types. Because this analysis shows association rather than direction, both PEBP4-to-partner and partner-to-PEBP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by PEBP4-low versus PEBP4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PEBP4→partner) and Y-score (partner→PEBP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	-0.055	-0.035	.001	.003	3	9
LUNG_SCLC	Heparan sulfate proteoglycan catabolic process →	+0.187	+0.024	<.001	.009	3	7
SOFT_TISSUE	Positive regulation of cellular respiration →	+0.122	+0.097	<.001	.003	3	7
UPPER_AERODIGESTIVE_TRACT	Response to unfolded protein →	+0.061	+0.164	.001	.004	3	6
SOFT_TISSUE	Protein exit from endoplasmic reticulum →	+0.076	+0.098	.001	.003	3	6
CNS	Proteoglycan catabolic process →	+0.112	+0.064	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,301 associations by consensus.

Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by PEBP4 expression — LARGE_INTESTINE

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