Across TCGA cell cohorts, PEAR1 mutation is significantly associated with the RNA expression of many other genes, with 1,649 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PEAR1-associated genes across cancer lineages are FBXW10, PIGY, and TRIM37. Each is linked with PEAR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEAR1-to-partner and partner-to-PEAR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEAR1→partner) and Y-score (partner→PEAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXW10 →	+0.180	+3.392	.001	.002	3	2
STOMACH	PIGY →	+0.964	+3.432	<.001	.008	3	2
LARGE_INTESTINE	TRIM37 →	+0.846	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	SEPSECS →	+0.717	+2.628	<.001	.002	3	2
LARGE_INTESTINE	CDK2AP1 →	+0.747	+3.169	<.001	.009	3	2
LARGE_INTESTINE	GPR63 →	+0.961	+2.628	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,649 associations by consensus.

Exploration

PEAR1 survival (RNA) · tumor vs normal (RNA) · all PEAR1 data types