Across TCGA patient cohorts, PEAK3 mutation is significantly associated with the RNA expression of many other genes, with 80 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEAK3-associated genes across cancer lineages are RNU6-1145P, FAM27B, and CENPNP1. Each is linked with PEAK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEAK3-to-partner and partner-to-PEAK3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEAK3→partner) and Y-score (partner→PEAK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-1145P →	+0.332	+5.368	<.001	.005	3	2
UCEC	FAM27B →	+0.111	+4.132	<.001	.009	3	2
LUSC	CENPNP1 →	+0.045	+4.339	.002	.007	3	2
HNSC	OR1E3 →	+0.044	+5.182	.001	.007	3	1
HNSC	RNU6-252P →	+0.347	+6.111	<.001	.002	3	1
HNSC	RN7SKP280 →	+0.215	+5.435	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

Exploration

PEAK3 survival (RNA) · tumor vs normal (RNA) · all PEAK3 data types