PEA15

Across TCGA pan-cancer cohorts, PEA15 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PEA15 data layer compared with 28 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PEA15 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PEA15 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRC and UCEC are the cancer types where PEA15 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.182	0.805	.003	15	view →
UCEC	DFS	Median	All	1.000	0.636	.036	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PEA15–KIRC (OS)

Open the KIRC breakdown →