PEA15

Across TCGA pan-cancer cohorts, PEA15 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PEA15’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PEA15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PEA15 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where PEA15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PEA15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.050	<.001	11	view →
HNSC	Female	IV	+1.104	<.001	10	view →
LIHC	Female	II,III,IV	+2.354	<.001	9	view →
KICH	Female	All	−1.352	<.001	8	view →
LUSC	All	II,III,IV	−0.615	<.001	6	view →
THCA	All	All	+0.347	<.001	6	view →
LUAD	Female	III,IV	−0.591	<.001	5	view →
COAD	Female	All	+0.602	.003	4	view →
CHOL	All	All	+2.920	<.001	3	view →
READ	Male	All	+1.156	.025	2	view →
PRAD	All	All	−0.260	.027	2	view →
ESCA	All	All	+0.793	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PEA15–KIRC

Open the KIRC breakdown →