PEA15

Across TCGA pan-cancer cohorts, PEA15 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PEA15 data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PEA15 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PEA15 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

COAD, LUAD, and PDAC are the cancer types where PEA15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.829	1.000	.027	36	view →
LUAD	DFS	Tertile	All	0.844	0.636	.011	9	view →
PDAC	OS	Quartile	All	0.761	0.442	.018	7	view →
LSCC	OS	Tertile	II,III,IV	0.678	0.917	.019	6	view →
HNSC	OS	Quartile	II,III,IV	0.576	0.812	.031	4	view →
GBM	OS	Median	All	0.450	0.629	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PEA15–COAD (DFS)

Open the COAD breakdown →