PEA15

Across TCGA patient cohorts, PEA15 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEA15-associated genes across cancer lineages are EGFR_pY1068, MEK1, and PDCD4. Each is linked with PEA15 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEA15-to-partner and partner-to-PEA15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PEA15-low versus PEA15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEA15→partner) and Y-score (partner→PEA15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.278	-2.115	.011	.019	3	1
UCEC	MEK1 →	+0.421	+2.807	.008	.003	3	1
UCEC	PDCD4 →	-0.576	-2.321	.005	.033	3	1
UCEC	PKC-a →	+0.355	+3.013	.044	.018	3	1
UCEC	Shc_pY317 →	-0.186	-2.115	.005	.019	3	1
UCEC	Src_pY527 →	-0.407	-2.999	.030	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by PEA15 expression — UCEC

Explore this box plot interactively →