PDZRN4

Across TCGA patient cohorts, PDZRN4 mutation is significantly associated with the RNA expression of many other genes, with 5,432 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDZRN4-associated genes across cancer lineages are IMP3, PKM, and RASGRP3-AS1. Each is linked with PDZRN4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PDZRN4-to-partner and partner-to-PDZRN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IMP3 grouped by PDZRN4-low versus PDZRN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZRN4→partner) and Y-score (partner→PDZRN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IMP3 →	+0.290	+1.584	<.001	<.001	3	4
COAD	PKM →	+0.558	+2.235	.001	.006	3	4
UCEC	RASGRP3-AS1 →	+0.365	+1.801	.001	.001	3	4
UCEC	NOCT →	+0.567	+1.662	<.001	.003	3	3
UCEC	GUF1 →	+0.437	+1.595	<.001	<.001	3	3
UCEC	BAG3 →	+0.531	+1.959	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,432 associations by consensus.

IMP3 by PDZRN4 expression — UCEC

Explore this box plot interactively →