PDZRN4

Across TCGA cell cohorts, PDZRN4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,544 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PDZRN4-associated GO terms across cancer lineages are Regulation of DNA repair, Chromosomal 5-methylcytosine DNA demethylation pathway, and Positive regulation of microglial cell migration. Each is linked with PDZRN4 in more than 6 cancer types. Because this analysis shows association rather than direction, both PDZRN4-to-partner and partner-to-PDZRN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA repair grouped by PDZRN4-low versus PDZRN4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZRN4→partner) and Y-score (partner→PDZRN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of DNA repair →	+0.044	+0.637	<.001	.001	3	7
BONE	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.147	+0.255	<.001	<.001	3	6
BONE	Positive regulation of microglial cell migration →	-1.172	-0.308	<.001	.004	3	5
BONE	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.131	+0.346	.002	<.001	3	5
SOFT_TISSUE	Cell cycle phase transition →	+0.048	+0.569	.003	.005	3	5
SOFT_TISSUE	Positive regulation of DNA repair →	+0.055	+0.585	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,544 associations by consensus.

Regulation of DNA repair by PDZRN4 expression — SOFT_TISSUE

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