PDZRN4

Across TCGA cell cohorts, PDZRN4 mutation is significantly associated with the RNA expression of many other genes, with 523 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDZRN4-associated genes across cancer lineages are OR8K3, NMRK1, and S100A1. Each is linked with PDZRN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDZRN4-to-partner and partner-to-PDZRN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8K3 grouped by PDZRN4-low versus PDZRN4-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZRN4→partner) and Y-score (partner→PDZRN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR8K3 →	+0.065	+4.196	<.001	.006	3	2
LARGE_INTESTINE	NMRK1 →	+0.703	+2.158	.008	.004	3	2
LARGE_INTESTINE	S100A1 →	-0.657	-2.584	.002	.002	3	2
LARGE_INTESTINE	GGT6 →	+1.907	+3.459	.001	.001	3	2
LARGE_INTESTINE	PDIK1L →	+0.477	+3.234	.009	.004	3	2
LARGE_INTESTINE	HDAC9 →	-1.167	-2.764	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 523 associations by consensus.

OR8K3 by PDZRN4 expression — BREAST

Explore this box plot interactively →