PDZRN3

Across TCGA patient cohorts, PDZRN3 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDZRN3-associated genes across cancer lineages are Caspase-7-cleavedD198, Chk2, and Claudin-7. Each is linked with PDZRN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both PDZRN3-to-partner and partner-to-PDZRN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PDZRN3-low versus PDZRN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZRN3→partner) and Y-score (partner→PDZRN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.566	+1.267	.001	.026	3	4
STAD	Chk2 →	+0.324	+3.000	.044	.036	3	3
STAD	Claudin-7 →	+0.915	+3.000	.007	.036	3	3
LUAD	Chk1 →	+0.190	+1.700	.037	.043	3	3
UCEC	BRCA2 →	-0.084	-2.278	.032	.033	3	3
LUSC	GAPDH →	+0.486	+1.289	.026	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Caspase-7-cleavedD198 by PDZRN3 expression — UCEC

Explore this box plot interactively →