PDZK1IP1

Across TCGA pan-cancer cohorts, PDZK1IP1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PDZK1IP1 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PDZK1IP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PDZK1IP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

HNSC, COAD, and PDAC are the cancer types where PDZK1IP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.893	0.656	.007	64	view →
COAD	DFS	Median	II,III,IV	1.000	0.838	.036	24	view →
PDAC	OS	Tertile	All	0.700	0.382	.012	18	view →
LUAD	OS	Tertile	All	0.371	0.903	.002	12	view →
UCEC	OS	Tertile	All	1.000	0.873	.015	8	view →
OV	DFS	Median	All	0.660	1.000	.033	4	view →
CCRCC	OS	Quartile	All	1.000	0.850	.022	3	view →
LSCC	OS	Median	II,III,IV	0.641	0.890	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PDZK1IP1–HNSC (OS)

Open the HNSC breakdown →