PDZK1

Across TCGA patient cohorts, PDZK1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDZK1-associated genes across cancer lineages are FOXO3a_pS318_S321, Gab2, and mTOR_pS2448. Each is linked with PDZK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDZK1-to-partner and partner-to-PDZK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by PDZK1-low versus PDZK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZK1→partner) and Y-score (partner→PDZK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.148	-2.990	.018	.036	3	1
UCEC	Gab2 →	+0.487	+3.000	.006	.036	3	1
UCEC	mTOR_pS2448 →	-0.206	-2.321	.006	.035	3	1
UCEC	B-Raf →	+0.356	+2.827	.049	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.215	-3.169	.011	.019	2	1
UCEC	p27 →	-0.250	-2.321	.023	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

FOXO3a_pS318_S321 by PDZK1 expression — UCEC

Explore this box plot interactively →