PDZD9

Across TCGA patient cohorts, PDZD9 mutation is significantly associated with the RNA expression of many other genes, with 368 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDZD9-associated genes across cancer lineages are TDGF1P1, MIR4445, and RN7SKP204. Each is linked with PDZD9 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDZD9-to-partner and partner-to-PDZD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TDGF1P1 grouped by PDZD9-low versus PDZD9-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD9→partner) and Y-score (partner→PDZD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	TDGF1P1 →	+0.084	+5.355	<.001	.005	3	2
UCEC	MIR4445 →	+0.248	+5.019	<.001	.001	3	2
UCEC	RN7SKP204 →	+0.243	+2.813	.006	.005	3	2
UCEC	MIR98 →	+0.318	+2.631	<.001	.007	3	1
UCEC	RNU6-6P →	+0.724	+2.170	<.001	.007	3	1
UCEC	CCL4 →	+1.130	+3.329	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 368 associations by consensus.

TDGF1P1 by PDZD9 expression — LIHC

Explore this box plot interactively →