PDZD9

Across TCGA pan-cancer cohorts, PDZD9 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PDZD9’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where PDZD9 RNA is repressed in tumor relative to normal tissue. In most cancer types PDZD9 is over-expressed in tumor, although a few such as LUSC and UCEC show the opposite, repressed pattern.

LUSC, UCEC, and BLCA are the cancer types where PDZD9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDZD9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−0.385	<.001	8	view →
UCEC	All	All	−0.376	<.001	8	view →
BLCA	All	All	−0.232	.001	8	view →
COAD	Male	All	−0.216	<.001	8	view →
LUAD	Female	III,IV	−0.492	<.001	6	view →
BRCA	All	III,IV	−0.274	<.001	6	view →
THCA	All	II,III,IV	−0.126	<.001	6	view →
READ	Male	All	−0.223	.048	2	view →
KICH	All	All	−0.151	.004	2	view →
PRAD	All	All	−0.104	.001	2	view →
KIRC	Male	All	−0.089	.001	2	view →
LIHC	All	All	+0.037	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PDZD9–LUSC

Open the LUSC breakdown →