PDZD9

Across TCGA cell cohorts, PDZD9 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDZD9-associated genes across cancer lineages are GSG1L2, STH, and KLF18. Each is linked with PDZD9 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDZD9-to-partner and partner-to-PDZD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by PDZD9-low versus PDZD9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD9→partner) and Y-score (partner→PDZD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSG1L2 →	+0.016	+4.437	<.001	.004	3	1
LARGE_INTESTINE	STH →	+0.127	+4.054	.002	.004	3	1
LARGE_INTESTINE	KLF18 →	+0.009	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

GSG1L2 by PDZD9 expression — LARGE_INTESTINE

Explore this box plot interactively →