PDZD8

Across TCGA patient cohorts, PDZD8 protein abundance is significantly associated with the protein abundance of many other proteins, with 17,015 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PDZD8-associated proteins across cancer lineages are ZFYVE27, CCDC186, and PDZD8_S538. Each is linked with PDZD8 in more than 7 cancer types. Because this analysis shows association rather than direction, both PDZD8-to-partner and partner-to-PDZD8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDZD8 versus ZFYVE27 in UCEC, with a Pearson correlation of 0.87.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD8→partner) and Y-score (partner→PDZD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZFYVE27 →	+0.916	+0.731	<.001	<.001	3	8
LSCC	CCDC186 →	+0.331	+0.279	<.001	<.001	3	8
UCEC	PDZD8_S538 →	+0.622	+0.564	<.001	<.001	3	6
UCEC	RAB24 →	+0.389	+0.534	<.001	<.001	3	6
UCEC	VTI1A →	+0.428	+0.511	<.001	<.001	3	6
PDAC	RNASEH2A →	-0.331	-0.417	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,015 associations by consensus.

PDZD8 vs ZFYVE27 — UCEC

Explore this scatter interactively →