PDZD8

Across TCGA pan-cancer cohorts, PDZD8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PDZD8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where PDZD8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PDZD8 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

KIRP, STAD, and COAD are the cancer types where PDZD8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDZD8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	+1.205	.003	8	view →
STAD	All	II,III,IV	+1.111	<.001	6	view →
COAD	Male	All	+0.773	<.001	6	view →
THCA	All	All	−0.418	.001	6	view →
UCEC	All	III,IV	+1.001	.029	4	view →
ESCA	All	II,III,IV	+1.084	.015	3	view →
CHOL	All	All	+1.205	.001	2	view →
BRCA	Female	All	−0.188	.025	2	view →
READ	Female	All	+0.700	.007	1	view →
LUAD	Male	All	+0.447	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PDZD8–KIRP

Open the KIRP breakdown →