PDZD8

Across TCGA patient cohorts, PDZD8 mutation is significantly associated with the RNA expression of many other genes, with 4,011 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDZD8-associated genes across cancer lineages are SLC3A2, PPIL4, and MMS22L. Each is linked with PDZD8 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDZD8-to-partner and partner-to-PDZD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC3A2 grouped by PDZD8-low versus PDZD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD8→partner) and Y-score (partner→PDZD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC3A2 →	+0.640	+2.212	<.001	<.001	3	3
UCEC	PPIL4 →	+0.410	+2.008	.009	.001	3	3
UCEC	MMS22L →	+0.312	+1.872	.005	.004	3	3
UCEC	MTA2 →	+0.430	+1.957	<.001	<.001	3	2
UCEC	INCENP →	+0.608	+2.201	<.001	.001	3	2
UCEC	EI24 →	+0.406	+1.893	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,011 associations by consensus.

SLC3A2 by PDZD8 expression — UCEC

Explore this box plot interactively →