PDZD8

Across TCGA patient cohorts, PDZD8 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDZD8-associated genes across cancer lineages are Cyclin-B1, A-Raf_pS299, and ACC1. Each is linked with PDZD8 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDZD8-to-partner and partner-to-PDZD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PDZD8-low versus PDZD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD8→partner) and Y-score (partner→PDZD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.774	+3.000	<.001	<.001	3	3
UCEC	A-Raf_pS299 →	-0.141	-2.502	<.001	.001	3	2
UCEC	ACC1 →	+0.277	+1.750	.025	.049	3	2
UCEC	PCNA →	+0.286	+3.000	<.001	<.001	3	2
UCEC	PDK1_pS241 →	+0.132	+2.000	.023	.009	3	2
UCEC	Rab25 →	-0.363	-2.137	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Cyclin-B1 by PDZD8 expression — UCEC

Explore this box plot interactively →