PDZD8

Across TCGA cell cohorts, PDZD8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,803 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDZD8-associated GO terms across cancer lineages are Viral translational termination-reinitiation, Regulation of intracellular steroid hormone receptor signaling pathway, and Random inactivation of X chromosome. Each is linked with PDZD8 in more than 14 cancer types. Because this analysis shows association rather than direction, both PDZD8-to-partner and partner-to-PDZD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral translational termination-reinitiation grouped by PDZD8-low versus PDZD8-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD8→partner) and Y-score (partner→PDZD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Viral translational termination-reinitiation →	+0.106	+0.953	<.001	<.001	3	15
STOMACH	Regulation of intracellular steroid hormone receptor signaling pathway →	+0.078	+1.233	.005	.007	3	13
BLOOD_Leukemia	Random inactivation of X chromosome →	+0.078	+1.425	<.001	<.001	3	12
BLOOD_Leukemia	Ornithine metabolic process →	+0.101	+1.308	.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol biosynthetic process →	+0.043	+0.736	<.001	<.001	3	11
SOFT_TISSUE	Protein deubiquitination →	+0.055	+1.005	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,803 associations by consensus.

Viral translational termination-reinitiation by PDZD8 expression — BREAST

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