PDZD8

Across TCGA cell cohorts, PDZD8 mutation is significantly associated with the RNA expression of many other genes, with 211 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDZD8-associated genes across cancer lineages are KRTAP10-4, H2BC1, and KRTAP13-2. Each is linked with PDZD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDZD8-to-partner and partner-to-PDZD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-4 grouped by PDZD8-low versus PDZD8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD8→partner) and Y-score (partner→PDZD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRTAP10-4 →	+0.089	+4.060	<.001	.003	3	2
LUNG_NSCLC_LUSC	H2BC1 →	+0.046	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	KRTAP13-2 →	+0.229	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	ARMH2 →	+0.020	+4.643	<.001	.008	3	1
URINARY_TRACT	CARTPT →	+0.015	+4.087	<.001	.009	3	1
URINARY_TRACT	CCDC197 →	+0.666	+4.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 211 associations by consensus.

KRTAP10-4 by PDZD8 expression — BLOOD_Leukemia

Explore this box plot interactively →