PDZD4

Across TCGA patient cohorts, PDZD4 mutation is significantly associated with the RNA expression of many other genes, with 3,270 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDZD4-associated genes across cancer lineages are C3AR1, TLE6, and RNU6-788P. Each is linked with PDZD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDZD4-to-partner and partner-to-PDZD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C3AR1 grouped by PDZD4-low versus PDZD4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD4→partner) and Y-score (partner→PDZD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	C3AR1 →	+0.806	+3.472	.006	.002	3	3
COAD	TLE6 →	+1.017	+3.199	<.001	.009	3	3
ESCA	RNU6-788P →	+0.361	+4.657	<.001	.003	3	3
UCEC	PKN3 →	+0.774	+2.379	<.001	<.001	3	3
UCEC	WDR41 →	+0.308	+1.815	.003	.002	3	3
UCEC	SFXN1 →	+0.429	+2.480	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,270 associations by consensus.

C3AR1 by PDZD4 expression — SKCM

Explore this box plot interactively →