PDZD4

Across TCGA pan-cancer cohorts, PDZD4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PDZD4’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PDZD4 RNA is repressed in tumor relative to normal tissue. In most cancer types PDZD4 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and KICH are the cancer types where PDZD4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDZD4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−4.012	<.001	11	view →
COAD	Male	II,III,IV	−2.015	<.001	11	view →
KICH	All	III,IV	−1.301	<.001	10	view →
THCA	All	III,IV	−0.791	<.001	10	view →
LUAD	Male	All	−1.115	<.001	8	view →
READ	All	All	−2.435	<.001	7	view →
HNSC	Male	II,III,IV	−0.531	.004	7	view →
UCEC	All	All	−3.071	<.001	6	view →
BRCA	All	All	−1.245	<.001	6	view →
STAD	All	All	−1.516	<.001	5	view →
LUSC	Female	II,III,IV	−1.515	<.001	5	view →
KIRP	Male	All	−0.646	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PDZD4–BLCA

Open the BLCA breakdown →