PDZD4

Across TCGA patient cohorts, PDZD4 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDZD4-associated genes across cancer lineages are eIF4E, Notch1, and C-Raf. Each is linked with PDZD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDZD4-to-partner and partner-to-PDZD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PDZD4-low versus PDZD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD4→partner) and Y-score (partner→PDZD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.189	+2.820	.004	.001	3	3
UCEC	Notch1 →	+0.137	+1.289	.002	.023	3	3
UCEC	C-Raf →	+0.169	+1.847	<.001	.007	3	3
UCEC	PI3K-p85 →	+0.156	+1.289	.019	.023	3	2
UCEC	S6_pS240_S244 →	+0.309	+2.700	.017	.006	3	2
UCEC	Src_pY527 →	-0.317	-1.797	.021	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

eIF4E by PDZD4 expression — UCEC

Explore this box plot interactively →