PDZD4

Across TCGA cell cohorts, PDZD4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,280 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PDZD4-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Cytokinesis, and Positive regulation of DNA repair. Each is linked with PDZD4 in more than 12 cancer types. Because this analysis shows association rather than direction, both PDZD4-to-partner and partner-to-PDZD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by PDZD4-low versus PDZD4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD4→partner) and Y-score (partner→PDZD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of double-strand break repair →	+0.079	+1.981	<.001	<.001	3	13
LUNG_SCLC	Cytokinesis →	+0.062	+1.778	.003	.008	3	13
BONE	Positive regulation of DNA repair →	+0.075	+2.498	<.001	<.001	3	13
BONE	Transcription initiation at RNA polymerase II promoter →	+0.080	+2.604	.008	.003	3	12
OESOPHAGUS	Nucleoside triphosphate metabolic process →	+0.124	+1.825	.001	.001	3	12
OESOPHAGUS	Purine nucleoside triphosphate metabolic process →	+0.120	+2.083	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,280 associations by consensus.

Positive regulation of double-strand break repair by PDZD4 expression — BONE

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