PDZD4

Across TCGA cell cohorts, PDZD4 mutation is significantly associated with the RNA expression of many other genes, with 267 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDZD4-associated genes across cancer lineages are MAGEL2, GZMK, and S100A7A. Each is linked with PDZD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDZD4-to-partner and partner-to-PDZD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEL2 grouped by PDZD4-low versus PDZD4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD4→partner) and Y-score (partner→PDZD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MAGEL2 →	+0.428	+4.133	<.001	.003	3	2
BREAST	GZMK →	+0.063	+5.169	<.001	.005	3	1
BLOOD_Lymphoma	S100A7A →	+0.035	+5.643	<.001	.002	3	1
LARGE_INTESTINE	DEPDC5 →	+0.527	+3.169	.006	.009	3	1
LARGE_INTESTINE	SAMM50 →	+0.572	+3.502	<.001	.001	3	1
LARGE_INTESTINE	AHSA1 →	+0.420	+2.451	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 267 associations by consensus.

MAGEL2 by PDZD4 expression — BLOOD_Leukemia

Explore this box plot interactively →