PDZD3

Across TCGA cell cohorts, PDZD3 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PDZD3-associated genes across cancer lineages are GPHB5, FAM47C, and ARMH2. Each is linked with PDZD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDZD3-to-partner and partner-to-PDZD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPHB5 grouped by PDZD3-low versus PDZD3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZD3→partner) and Y-score (partner→PDZD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GPHB5 →	+0.130	+5.977	<.001	.001	3	1
SOFT_TISSUE	FAM47C →	+0.006	+5.369	.009	.004	3	1
SOFT_TISSUE	ARMH2 →	+0.054	+4.930	<.001	.008	3	1
LUNG_NSCLC_LUSC	BHLHE23 →	+0.020	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	SLC2A7 →	+0.013	+4.643	<.001	.008	3	1
BLOOD_Leukemia	LUZP4 →	+0.485	+5.060	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

GPHB5 by PDZD3 expression — SOFT_TISSUE

Explore this box plot interactively →