PDYN

Across TCGA patient cohorts, PDYN mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible PDYN-associated genes across cancer lineages are JNK2, MEK1_p_S217_S221, and Akt_pT308. Each is linked with PDYN in more than 2 cancer types. Because this analysis shows association rather than direction, both PDYN-to-partner and partner-to-PDYN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PDYN-low versus PDYN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDYN→partner) and Y-score (partner→PDYN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	JNK2 →	-0.251	-3.459	.002	.004	3	3
LUSC	MEK1_p_S217_S221 →	+0.182	+2.468	.005	.011	3	2
UCEC	Akt_pT308 →	+0.704	+3.169	.020	.019	3	2
LUSC	PKC-b-II_pS660 →	-0.424	-2.450	.002	.019	3	2
LUSC	AMPK_pT172 →	-0.479	-3.321	<.001	.009	3	2
SKCM	Syk →	-0.464	-1.807	.021	.026	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

JNK2 by PDYN expression — SKCM

Explore this box plot interactively →