PDYN

Across TCGA pan-cancer cohorts, PDYN RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated PDYN data layer compared with 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PDYN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDYN expression acts as an unfavorable survival marker, although some lineages such as SKCM and PAAD show a favorable association.

UCEC, BLCA, and COAD are the cancer types where PDYN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.513	0.687	<.001	48	view →
BLCA	DFS	Tertile	All	0.495	0.636	.002	42	view →
COAD	OS	Tertile	IV	0.188	0.686	<.001	36	view →
BRCA	DFS	Quartile	II,III,IV	0.842	0.905	.004	31	view →
DLBC	OS	Tertile	II,III,IV	0.545	1.000	.006	28	view →
KIRC	DFS	Tertile	IV	0.148	0.423	.001	24	view →
SKCM	DFS	Quartile	All	0.328	0.193	.001	20	view →
LUSC	DFS	Tertile	III,IV	0.223	0.724	.014	13	view →
PAAD	DFS	Tertile	All	0.433	0.212	.028	9	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	9	view →
LIHC	OS	Tertile	II,III,IV	0.528	0.736	.011	9	view →
LUAD	DFS	Quartile	III,IV	0.455	0.706	.024	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

PDYN–UCEC (DFS)

Open the UCEC breakdown →