PDYN

Across TCGA cell cohorts, PDYN mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PDYN-associated genes across cancer lineages are ANTXRL, OR2S2, and OR10W1. Each is linked with PDYN in more than 1 cancer types. Because this analysis shows association rather than direction, both PDYN-to-partner and partner-to-PDYN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANTXRL grouped by PDYN-low versus PDYN-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDYN→partner) and Y-score (partner→PDYN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ANTXRL →	+0.041	+4.070	.008	.003	3	1
LUNG_SCLC	OR2S2 →	+0.164	+3.523	.001	.008	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ANTXRL by PDYN expression — LUNG_SCLC

Explore this box plot interactively →