PDXP

Across TCGA patient cohorts, PDXP mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDXP-associated genes across cancer lineages are FoxM1, FOXO3a_pS318_S321, and MAPK_pT202_Y204. Each is linked with PDXP in more than 1 cancer types. Because this analysis shows association rather than direction, both PDXP-to-partner and partner-to-PDXP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by PDXP-low versus PDXP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDXP→partner) and Y-score (partner→PDXP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.371	+3.169	.008	.020	3	1
UCEC	FOXO3a_pS318_S321 →	-0.142	-2.990	.038	.036	3	1
UCEC	MAPK_pT202_Y204 →	-0.598	-3.000	.020	.036	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.596	-3.000	.015	.036	3	1
UCEC	p62 Lck ligand →	+0.652	+3.179	<.001	.010	3	1
UCEC	Src_pY416 →	-0.298	-3.156	.024	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

FoxM1 by PDXP expression — UCEC

Explore this box plot interactively →