PDXP-DT

Across TCGA pan-cancer cohorts, PDXP-DT RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PDXP-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PDXP-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDXP-DT expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

KIRC, UCS, and HNSC are the cancer types where PDXP-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.560	0.686	<.001	127	view →
UCS	DFS	Median	III,IV	0.633	0.210	<.001	64	view →
HNSC	OS	Median	II,III,IV	0.697	0.597	.006	26	view →
THCA	OS	Quartile	II,III,IV	0.876	1.000	.003	25	view →
BLCA	OS	Tertile	All	0.760	0.662	.023	22	view →
STAD	OS	Median	All	0.679	0.381	.004	22	view →
MESO	DFS	Tertile	II,III,IV	0.323	0.673	.019	21	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	21	view →
KIRP	DFS	Quartile	III,IV	0.204	0.784	.003	16	view →
LGG	OS	Median	All	0.609	0.425	<.001	16	view →
CESC	OS	Median	II,III,IV	0.909	0.729	.005	14	view →
UVM	OS	Tertile	All	0.850	0.537	.025	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PDXP-DT–KIRC (DFS)

Open the KIRC breakdown →