PDXP-DT

Across TCGA pan-cancer cohorts, PDXP-DT RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PDXP-DT’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where PDXP-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PDXP-DT is over-expressed in tumor.

LUSC, LUAD, and HNSC are the cancer types where PDXP-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDXP-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	+0.309	<.001	7	view →
LUAD	All	All	+0.167	<.001	6	view →
HNSC	All	All	+0.093	.001	6	view →
KIRC	All	All	+0.037	.002	5	view →
STAD	All	II,III,IV	+0.244	.006	4	view →
READ	Female	All	+0.449	.001	2	view →
UCEC	All	All	+0.122	.016	2	view →
KIRP	All	All	+0.058	.016	1	view →
KICH	Female	III,IV	+0.053	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PDXP-DT–LUSC

Open the LUSC breakdown →