PDX1

Across TCGA patient cohorts, PDX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,896 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible PDX1-associated GO terms across cancer lineages are Sugar mediated signaling pathway, Response to iron(II) ion, and Negative regulation of chromosome organization. Each is linked with PDX1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PDX1-to-partner and partner-to-PDX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sugar mediated signaling pathway grouped by PDX1-low versus PDX1-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDX1→partner) and Y-score (partner→PDX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Sugar mediated signaling pathway →	-0.190	-1.228	<.001	.001	3	13
SCLC	Response to iron(II) ion →	-0.167	-1.028	<.001	<.001	3	12
LUSC	Negative regulation of chromosome organization →	+0.033	+0.436	<.001	<.001	3	12
TGCT	Regulation of nuclear division →	+0.046	+0.796	<.001	<.001	2	13
BLCA	DNA-templated DNA replication maintenance of fidelity →	+0.027	+0.617	<.001	<.001	3	11
TGCT	Positive regulation of mitotic cell cycle →	+0.037	+0.819	<.001	.001	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,896 associations by consensus.

Sugar mediated signaling pathway by PDX1 expression — SCLC

Explore this box plot interactively →