PDX1

Across TCGA pan-cancer cohorts, PDX1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PDX1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PDX1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PDX1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

COAD, STAD, and HNSC are the cancer types where PDX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+3.877	<.001	12	view →
STAD	All	II,III,IV	+2.121	<.001	8	view →
HNSC	All	All	+0.290	.001	8	view →
BLCA	Male	All	+1.043	.007	6	view →
LUAD	All	All	+0.710	<.001	6	view →
LUSC	All	II,III,IV	+0.592	<.001	6	view →
BRCA	Female	All	+0.081	.019	4	view →
THCA	All	II,III,IV	−0.017	.005	4	view →
READ	All	All	+2.776	.001	3	view →
ESCA	All	All	+2.289	.019	3	view →
LIHC	Female	All	+0.825	.011	3	view →
KIRC	Male	All	−0.077	.004	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PDX1–COAD

Open the COAD breakdown →