PDX1

Across TCGA patient cohorts, PDX1 protein abundance is significantly associated with the protein abundance of many other proteins, with 2,892 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PDX1-associated proteins across cancer lineages are ARVCF_S864, ARVCF_S887, and ATAT1_S276. Each is linked with PDX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDX1-to-partner and partner-to-PDX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDX1 versus ARVCF_S864 in PDAC, with a Pearson correlation of 0.41.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PDX1→partner) and Y-score (partner→PDX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ARVCF_S864 →	+0.963	+0.688	<.001	<.001	3	1
PDAC	ARVCF_S887 →	+0.932	+0.687	<.001	<.001	3	1
PDAC	ATAT1_S276 →	-0.353	-0.429	.001	.001	3	1
PDAC	ATF7IP_S445 →	-0.584	-0.604	<.001	<.001	3	1
PDAC	ATG12 →	-0.465	-0.495	.001	.004	3	1
PDAC	ATG16L1_S269 →	-1.045	-0.449	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,892 associations by consensus.

PDX1 vs ARVCF_S864 — PDAC

Explore this scatter interactively →